The essence of TCM is the holistic concept and evidence-based treatment, and TCM must follow this rule in treating infertility in order to achieve good results. Infertility is not an independent disease, but is the result of many gynecological diseases. Clinical diagnosis of infertility in TCM is divided into evidence types such as kidney qi deficiency, kidney yin deficiency, kidney yang deficiency, liver qi stagnation, and phlegm-dampness obstruction. The most common type of infertility is liver qi stagnation, which mainly manifests as infertility after marriage for a long time, early or postponed menstruation, low menstrual flow, chest distension and pain, and abnormal emotions; the commonly used formula is Kai Yu Seed Jade Tang in Fu Qing Zhuang Women’s Medicine, which mainly contains Chinese herbs such as Chai Hu, Xiang Shen, Dan Pi and pollen, which play a role in helping pregnancy. The main manifestations are infertility after marriage for a long time, obesity, low menstrual flow, excessive leucorrhea and sticky texture; the commonly used formula is Cangfu Guiding Phlegm Pill, which mainly includes Cangzhi, Xiangxiang and Biananxing, which can dispel dampness and expel phlegm. In conclusion, infertility is a complex disease in clinical practice, and joint treatment of both men and women is advocated in its treatment.