After 20 years of “asthma”, 1 year of “vocal cord paralysis” and 3 tracheal surgeries, Mr. Liu’s painful life was all gone after 30 minutes of radiofrequency treatment in the hospital. The “gastroesophageal laryngotracheal syndrome” theory proposed by the academician of the Chinese Academy of Sciences has helped to find the real cause for a considerable number of patients who were misdiagnosed as “asthma” and “vocal cord paralysis”, and successfully The treatment was successful. Mr. Liu, 52, developed a cough, sputum, and difficulty with inhalation 20 years ago. First, he was diagnosed with “asthma” in the Department of Whistling and took medication for 20 years, but his condition got worse and worse, and he was often awakened in the middle of the night by breath-holding. Later, the ENT department diagnosed him with “vocal cord paralysis” and took a temporary life-saving measure – tracheotomy. After that, Mr. Liu underwent two more vocal cord openings, but they were not a cure. Later, Mr. Liu learned during a physical examination that a significant number of asthma patients may be caused by GERD and came to the hospital’s GERD center for consultation. After 24-hour esophageal PH monitoring, Mr. Liu was diagnosed with moderate gastroesophageal reflux, which is typical of gastroesophageal laryngotracheal syndrome. This disease is caused by the relaxation of the cardia and other reasons, causing the contents of the stomach to reflux upward through the esophagus to the throat, bringing coughing, sputum, otorhinitis, etc., as well as laryngotracheal spasm and contraction caused by gastric acid stimulation, which in turn causes airway narrowing or vocal occlusion, manifesting as inspiratory difficulties, which can be life-threatening in severe cases. This symptom of Mr. Liu is in line with the theory of gastroesophageal laryngotracheal syndrome, which was researched and proposed by academicians, and is not an ordinary “asthma” disease. According to the symptoms, half of the patients with “asthma” may have been misdiagnosed. The main symptom of “asthma” caused by gastroesophageal laryngotracheal syndrome differs from ordinary asthma in that ordinary asthma often has allergens such as pollen, dust mites, etc., and the condition can worsen or lessen with seasonal or environmental changes, mainly with difficulty in whistling. In contrast, patients with gastroesophageal laryngotracheal syndrome “asthma” often do not find obvious allergens, and have long-standing illnesses that do not have a seasonal distribution, mainly due to laryngeal spasms, which are characterized by difficulty in breathing and easily awakened by breath-holding in the middle of the night, and some patients also have nausea and heartburn.