Headache and vomiting. The first consideration is a headache with vomiting, the most common clinical disorder is migraine. Migraine is a disease of unknown etiology and is currently clinically considered to be related to genetic factors, metabolic and endocrine factors as well as environmental and psychiatric factors. For migraine headache with no positive CT or MRI, if the pain is particularly obvious in the acute stage, oral non-steroidal anti-inflammatory drugs, such as acetaminophen and ibuprofen, can be considered, as well as oral treprostatin or ergotamine. Secondly, headache with vomiting can also be seen in cerebrovascular diseases, clinically, cerebral infarction in ischemic cerebrovascular diseases and cerebral hemorrhage in hemorrhagic diseases are most common, and the diagnosis can be confirmed by head CT and MR examination. Treatment should be directed at ischemia and hemorrhage. Then headache with vomiting can also be seen in hypertensive encephalopathy, when the patient has a history of hypertension, when the blood pressure exceeds 200/100mmHg, the patient appears headache with vomiting, it is recommended to take oral antihypertensive drugs and monitor the change of blood pressure.