Brain atrophy with white matter demyelination means that the patient’s brain tissue is atrophied and the white matter of the brain is demyelinated, which is related to the destruction of phospholipid cells. Usually, aging of the brain tissue and vitamin B12 deficiency can lead to white matter demyelination and brain atrophy. In some cases, the disease may be caused by viral or bacterial infections. This disease can lead to symptoms such as dizziness, loss of interest and memory loss. When examination reveals brain atrophy with brain white matter demyelination changes, patients need to pay attention to clarify the specific causes and carry out targeted treatment to avoid further damage to brain tissue. Severe cerebral atrophy and white matter demyelination can also lead to cerebral infarction and even pose a threat to the patient’s life. It is recommended that patients under the guidance of professional doctors for standardized diagnosis and treatment.