The timing of medication administration in patients with coronary artery disease depends on 3 factors: disease characteristics, drug properties, and the person’s biological clock. It has been found that the incidence of cardiac events is significantly higher in the early morning hours after waking up and moving around than in other time periods, usually from 10 to 12 am. Therefore, patients with coronary heart disease should preferably take their medication in the morning or even wake up and take it on an empty stomach to prevent cardiac events after waking up in the morning. However, many elderly people worry that taking medication on an empty stomach is very stimulating to the stomach and intestines, so they usually take medication after breakfast, this worry is superfluous. Generally, except for anti-platelet drugs and statin lipid regulating drugs, other drugs are not very stimulating to the stomach and intestines, and you can also drink some milk or eat some cake after waking up in the morning and take the medication, so you can have the best of both worlds. Therefore, patients with coronary artery disease should preferably take their medication in the morning. Unless otherwise specified by the doctor, patients should find out the right time to take their medication according to their actual situation.