The absence of pain after chemotherapy for esophageal cancer is generally considered to be a phenomenon of improvement, or it is considered to be due to the insignificant adverse reaction of patients after chemotherapy. Esophageal cancer is a kind of common malignant tumor, and patients often have various clinical symptoms such as difficulty in swallowing, subglottic pain, etc. If patients’ pain symptoms are obviously reduced or disappeared after chemotherapy, it often represents that chemotherapy is effective and the lesion of esophageal cancer shrinks, and thus the pain symptoms are reduced or disappeared, which is a phenomenon of improvement of esophageal cancer lesion. Some esophageal cancer patients do not have pain symptoms before chemotherapy, and the gastrointestinal adverse reactions caused by chemotherapeutic drugs are relatively mild, so they do not have abdominal pain, pain in swallowing and other discomforts. Of course, the effect of chemotherapy cannot be judged only by whether there is pain or not. During chemotherapy, regular review is needed to monitor the effect of treatment and adverse reactions, and if there is any discomfort, consult the doctor in time to avoid delaying the condition.