Glucocorticoids and cytotoxic drugs are still the main drugs used in the treatment of nephrotic syndrome. Patients with nephrotic syndrome who have contraindications to hormones and do not use hormones can use cytotoxic drugs and so on.
Nephrotic syndrome is mainly manifested by massive proteinuria, hypoproteinemia, hyperlipidemia and edema, and the therapeutic drugs mainly include glucocorticoid and cytotoxic drugs.
1. Glucocorticoid: It can inhibit the immune inflammatory reaction, inhibit the secretion of aldosterone and antidiuretic hormone, and affect the permeability of glomerular basement membrane to play its diuretic and eliminate the therapeutic effect of urinary protein. Whether or not to use hormones in nephrotic syndrome should be based on the type of pathology, treatment response, such as microscopic lesion type nephropathy is generally sensitive to hormones.
According to the patient’s therapeutic response to glucocorticoids, it can be divided into “hormone-sensitive” (nephrotic syndrome remission within 8 to 12 weeks of medication), “hormone-dependent” (hormone reduction to a certain extent, that is, the recurrence of hormone) and “hormone resistance” (conventional hormone therapy is ineffective). Hormone-dependent” (relapse when the hormone is reduced to a certain extent) and “hormone-resistant” (ineffective in conventional hormone therapy).
2. Cytotoxic drugs: cytotoxic drugs can be used for “hormone-dependent” or “hormone-resistant” patients, synergistic hormone therapy. If there is no contraindication to hormone, it is generally not preferred or used as a separate treatment; if there is a contraindication to hormone, cytotoxic drugs can be used, including cyclophosphamide, nitrogen mustard phenylbutyrate and other specific drugs.
Patients with nephrotic syndrome should go to the hospital in time, and develop a medication program under the guidance of a professional physician.