Gout can be divided into primary gout and secondary gout, primary gout is caused by genetic factors and environmental factors, secondary gout is mainly due to kidney disease, drugs, tumor chemotherapy or radiotherapy. 1. Primary gout: the vast majority of uric acid excretion disorders, with a certain family susceptibility, may be associated with inborn defects in purine metabolism enzymes in the body, long-term high-purine diet, obesity, as well as long-term alcohol consumption is a predisposing factor. 2. Secondary gout: long-term use of diuretics such as hydrochlorothiazide, azathioprine and other chemotherapy drugs, cyclosporine and other chemotherapy drugs can cause elevated blood uric acid levels, resulting in gouty attacks. It should be noted that clinically only 5% to 15% of patients with hyperuricemia will develop gout, long-term urate crystal deposition invites monocytes, epithelial cells and macrophages infiltration, the formation of foreign body nodules that is gout stone.