Numbness of hands and feet in middle-aged and old people may be caused by prolonged drinking, diabetes, cervical and lumbar spondylosis, cerebrovascular lesions and other factors. 1. Prolonged alcohol consumption: prolonged alcohol consumption by middle-aged and elderly people may lead to peripheral neuropathy, nerve damage, there will be numbness in the hands and feet, which may also be accompanied by sensory abnormalities. 2. Diabetes: it may be related to poor genetics, living habits and other factors, long time diabetes, resulting in neuropathy, will cause numbness of the hands and feet, may also be accompanied by fatigue, drinking, eating, frequent urination and other symptoms. 3. Cervical and lumbar spondylosis: when middle-aged and elderly people suffer from cervical spondylosis and lumbar spondylosis, the nerves innervating the upper limbs or lower limbs may be compressed, which will lead to numbness of the hands and feet, and may be accompanied by upper limb radiating pain, lower limb radiating pain and other symptoms. 4. Cerebrovascular lesions: for example, cerebral hemorrhage, cerebral thrombosis, etc., can lead to numbness of the hands and feet, which may also be accompanied by speech disorders, dizziness, headache, nausea, vomiting and other symptoms. The numbness of hands and feet in middle-aged and old people, lasting for a long time, it is recommended to consult a doctor for examination and treatment in time to avoid delaying the condition.