A creatinine of 112 μmol/L is on the high side and is generally not serious, but whether it is serious or not depends on the etiology, which can be physiologic or pathologic. Physiologic elevations are usually not serious, while pathologic elevations are relatively serious. Creatinine is mainly used to evaluate the glomerular filtration function, the normal value of creatinine in adult men in China is 53-106μmol/L, and the normal value of creatinine in women is 44-97μmol/L, the reference range of different hospitals is slightly different. Creatinine 112μmol / L belongs to the high, can be seen in physiological and pathological reasons. 1. Physiological elevation is mostly seen after a lot of exercise or eating a lot of meat food, which will enhance the muscle metabolism, creatinine production will increase, blood creatinine may be 112μmol/L, but after rest or vegetarian diet, blood creatinine will return to the normal level, and this time is not serious. 2. Pathological elevation can be seen in such as acute and chronic renal failure, other secondary kidney disease such as diabetic nephropathy, etc.; and the degree of creatinine increase and the severity of renal disease is consistent with the degree of chronic renal failure is irreversible, at this time, the creatinine 112 μmol / L, relatively serious, pay attention to the regular review, need to be under the guidance of the doctor’s medication to slow down the progress of the disease. When the patient creatinine 112μmol / L, it is recommended to consult a regular hospital in a timely manner, under the guidance of nephrologist, the appropriate examination, clear diagnosis and symptomatic treatment, regular review and observation, so as not to delay the condition.