Elderly people may experience side effects such as dependence, habitual constipation, and chronic inflammation of the intestinal mucosa with the use of corkscrew. 1. Dependence: Keselol is mainly a lubricant drug composed of glycerin and other auxiliary drugs, which can help patients to defecate quickly in a short period of time to relieve the discomfort of constipation after the application of the elderly, due to its high efficiency, it can make the patients dependent on the use of Keselol to defecate through the use of constipation, once constipated, they will give up the voluntary defecation. 2. Habitual constipation: long-term use of Kefir can cause the intestinal wall dry, the elderly application of Kefir more often, the intestinal wall will be more and more dry, sensitivity is getting worse and worse, which leads to more and more difficult for the patient to defecate, causing habitual constipation. 3. Chronic intestinal mucosal inflammation: Keselol in the use of the process, the drug itself and the plastic bottle can play a stimulating effect on the rectal mucosa, may cause strong contraction of local tissues, so that the intestinal mucosa is damaged, thus triggering chronic intestinal mucosal inflammation. It is recommended that Keseluk should be used under the guidance of a physician, and should not be used without authorization.