Emptiness of the heart may be due to physiological factors, and may also be related to myocardial ischemia and premature ventricular contractions. 1. physiological factors: may be due to the recent work encountered things do not go well, this time the mood is low, feeling abnormal, there may be a feeling of empty heart, accompanied by poor mental state, body weakness and other clinical manifestations, in the mood stabilization, the discomfort symptoms will gradually disappear. 2. Myocardial ischemia: The empty heart usually belongs to the manifestation of myocardial ischemia, accompanied by the feeling of pressure in the chest area and burning sensation. Especially women who report panic or empty heart when walking are more typical manifestations of myocardial ischemia. 3. Premature ventricular contraction: It mainly refers to abnormal early contraction of the ventricular part of the heart, which is clinically more common as arrhythmia, accompanied by low blood pressure, palpitations (accelerated heartbeat, often accompanied by panic), and it will be manifested as a momentary sense of excitement, and it always feels that the heart is empty, similar to the weightlessness of the elevator’s rapid rise and fall. If the heart is empty, it is recommended to consult a doctor in time to improve the relevant examination, to clarify the cause of the disease, and follow the doctor’s instructions for targeted treatment.