The generic name of Tonicare is estradiol valerate. The drug is used to treat estrogen deficiency and other conditions that require long-term medication, but requires a condition assessment every six months to decide whether to continue the drug. Estradiol valerate is an estrogenic drug that is commonly used clinically to treat estrogen deficiency, difficulty having sexual intercourse, sleep disorders, and other conditions. Unless otherwise prescribed, prolonged use of estradiol is usually required to achieve stable therapeutic effect, and a reassessment of the condition and the pros and cons of the medication is required every six months in order to adjust or discontinue the treatment if necessary. If adverse reactions such as allergy, purpura, urticaria, etc. occur during the use of estradiol valerate, it is necessary to go to the hospital for consultation. The use of Estradiol Valerate is contraindicated during pregnancy and lactation, abnormal vaginal bleeding, suspected or confirmed breast cancer, liver tumor, arterial thromboembolism, severe hyperesterolemia, and drug allergy. Estradiol valerate is a hormone drug and needs to be used under the guidance of a clinician.