Blisters are medically referred to as blisters. Blisters on the forefoot and pain when pressed are usually symptoms of friction blisters, burns blisters, and sweat blisters, and require prompt hospitalization to clarify the cause of the disease, and the treatment plan includes general treatment and medication and other methods. 1. Friction blisters are caused by walking or standing for a long period of time, and are mostly seen in heavy manual laborers. It manifests as a large blister on the forefoot, and the liquid inside the blister is clarified and easily broken. Treatment can be used to draw out the liquid in the blister with a syringe, and at the same time apply mupirocin ointment, erythromycin ointment and other antiseptic and anti-inflammatory ointment treatment. 2. Scalded blisters are caused by contact with hot water and high temperature items on the feet, manifested as a large redness of the skin on the feet, erythema with more blisters and vesicles, accompanied by obvious pain and tenderness. Scalding blisters can be treated by applying Jingwanhong ointment or moist burn cream. 3. Sweat herpes is caused by a variety of factors, is a special type of eczema, preferably on the palms of the hands and feet. The manifestation is the appearance of deep subcutaneous blisters on the palms of the feet, blisters blister wall is thicker, there is obvious itching sensation, pressure and walking with mild tingling. Sweat blisters can be treated with topical glucocorticoid creams such as hydrocortisone butyrate cream or mometasone furoate cream. There may be other reasons for the appearance of the above conditions, it is recommended to visit the hospital to identify the cause, and medications need to be used as prescribed by the doctor.