There is no fastest and most effective way to reduce fever, fever should be based on the cause of fever and symptoms to choose the appropriate treatment. 1. Infection of bacteria, viruses, mycoplasma, etc. can appear fever, first of all, to clarify the infection of which pathogenic bacteria, bacterial infections generally oral cephalosporin, viral infections oral oseltamivir and so on. Symptomatic antipyretic can be given physical cooling, if necessary, follow the doctor’s instructions to give oral medication antipyretic treatment. 2. Autoimmune diseases can also appear fever, such as systemic lupus erythematosus, need to titrate glucocorticoids combined with immunosuppressive drugs to reduce fever, such as prednisone, cyclophosphamide and so on. 3. Tumor patients will have tumor fever, which is manifested as fever, and can be physically cooled down by ice packs, alcohol wipes, etc. For those whose temperature does not drop, drugs such as ibuprofen can be taken. At the same time, the tumor should be actively treated. Fever can also be seen as heatstroke, drug intoxication, etc. If the temperature does not decrease by physical means such as ice compresses or when there are symptoms such as convulsions, one should go to hospital for consultation in time.