Monkeypox is a contagious viral infection, we need to do a good job of self-protection, avoid contact with sick animals, keep a social distance, wash your hands diligently, hygienic, can be vaccinated against smallpox. Monkeypox can be transmitted from sick animals to human beings and also through daily contact between people, so we need to do our daily self-protection, avoid contact with sick animals, maintain a certain social distance, and be diligent in hand washing and hygiene in daily life. Because monkeypox virus and smallpox virus are the same kind of virus, so the smallpox vaccination in China can prevent monkeypox infection to a certain extent and provide immune protection for the body. Prevention of monkeypox should start from oneself. If infected, one should consult a doctor immediately to avoid delay and spread of the disease.