The main reason for acid reflux in bed at night is the consumption of acidic food, but it may also be caused by gastroesophageal reflux disease, duodenal ulcer, etc. It is recommended to go to the hospital for appropriate treatment. A. Physiological causes: If the stomach acid reflux occurs once in a while at night, it is considered to be caused by excessive secretion of stomach acid due to eating acidic food at dinner. In addition, if you eat too much at night, it will also cause too much secretion of stomach acid, the secreted stomach acid will stay in the upper end of the stomach body, it is easy to sleep at night stomach acid reflux situation. Usually pay attention to avoid overeating before going to bed, avoid eating too acidic food, discomfort symptoms will be relieved. Second, pathological causes: 1, gastroesophageal reflux disease: esophagogastric junction of the lower esophageal sphincter, diaphragm and nearby muscle bundles and ligaments, etc., the synergistic effect is weakened, can not form a high-pressure belt at the gastroesophageal junction, gastric contents will reflux to the esophagus, and then reflux to the trachea, can appear at night to sleep stomach acid reflux situation. It can be treated by oral acid inhibiting drugs such as omeprazole or lansoprazole to relieve the discomfort. In addition, do not lie in bed immediately after eating, do not eat within two hours before bedtime, you can raise the head of the bed 15-20 cm; 2, duodenal ulcer: due to the invasive effect of gastric acid, pepsin and duodenal mucosa defense capacity out of balance, high gastric acid activates pepsin, digestive capacity exceeds the defense capacity of the mucosa, so that it digests its own intestinal mucosa leading to the occurrence of duodenal ulcer. Patients with significantly increased secretion of gastric acid will experience acid reflux, which may be accompanied by epigastric pain during fasting. Patients are recommended to undergo endoscopy and apply drugs that inhibit gastric acid secretion, such as ranitidine, famotidine, cimetidine, etc., for treatment after diagnosis.