Vitiligo is a common acquired pigment loss skin and mucous membrane disease that can involve hair follicles and clinically manifest as white patches or (and) white hair. Vitiligo is often treated with topical hormonal creams and topical calcineurin inhibitors. Oral medications are not the first line of treatment for vitiligo, and oral hormones can be taken when the condition is severe. 1. topical drugs (1) Hormone creams: common drugs are fluticasone propionate, halometasone, etc., which can prevent proliferation and restore some of the color of the skin. (2) Calcium-modulated neural phosphatase inhibitors: for adults and children, especially the face, mucous membranes and thin and tender parts, can choose 0.03%, 0.1% tacrolimus ointment or 1% pimecrolimus cream application. (3) Vitamin D3 derivatives: topical capotriol or tacalcitol ointment can be used, combined with NB-UVB can enhance the efficacy. 2. Oral medications: Common medications include glucocorticosteroids such as prednisone, which are only suitable for patients in the progressive stage and can help control the development of the disease. The above drugs are recommended to be used under the guidance of a doctor. If you are diagnosed with vitiligo, it is recommended that you go to the hospital in time and choose the appropriate method of treatment under the guidance of your doctor.