With male genital ulcers, there are three diseases that this should be aware of. The first is probably an inflammatory genital reaction, resulting in a local ulcer, which can be cured by cleaning and then taking a broad-spectrum oral antimicrobial. The second is to pay attention to whether it is syphilis infection, syphilis is in the genital ulcers, there is a history of unclean sexual intercourse, through the blood test can confirm whether it is syphilis infection. Syphilis should be treated with high doses of penicillin, followed by long-acting penicillin, which usually takes two to three months of treatment. Thirdly, it may be necessary to pay attention to the possibility of penile cancer. Penile cancer is mainly a long-term untreated ulcer, and the diagnosis can be confirmed by taking tissue for pathological examination.