High urinary retinol binding protein is due to damage to the proximal tubule of the kidney. This binding protein is mainly produced in the liver and flows through the blood and various tissue fluids to the kidney, where it is excreted by filtration from the renal tubules. If there are problems in the kidneys, such as tubular damage or a decrease in the glomerular filtration rate, which leads to excessive excretion of metabolites from the body, high levels of retinol-binding protein may result. This substance is mainly metabolized in the proximal tubule of human kidney, so the abnormal excretion mainly indicates the occurrence of disease in the proximal tubule of the kidney. Taking drugs containing nephrotoxicity is prone to this condition, which requires timely discontinuation of the drug and at the same time targeted treatment to avoid delaying the condition and leading to kidney failure, otherwise the treatment content is quite cumbersome and may even endanger the life of the individual.