In the early stages of pregnancy, estradiol will gradually increase in the pregnant woman’s body, and as the pregnancy cycle grows up to the third trimester, the growth of estradiol will increase significantly. As the placenta has already grown and developed during this period, the placenta will secrete estrogen, progesterone and other related hormones to maintain the growth and development of the embryo, which will result in the phenomenon of significantly higher estradiol. If estradiol increases significantly in pregnant women, we cannot rule out the possibility that it is due to organic diseases such as uterine fibroids. If estradiol is significantly lower, it will have a certain impact on the growth and development of the embryo, and in some cases, it may even cause pre-term miscarriage or miscarriage and other diseases. It is recommended that patients should take estrogen test regularly to clarify the growth and development of the fetus, so as to facilitate timely detection of the disease and timely treatment.