How to combine spironolactone and furosemide should be selected according to different diseases, heart failure should be combined according to the principle of from big to small, while cirrhosis should be combined according to the principle of from small to big, and the combined use of diuretics can play a role in increasing the effect of diuresis and maintaining the stability of potassium metabolism in the body. 1. Heart failure: first give large dose of diuretic, then gradually reduce the dosage, can adopt the ratio of 2:1 for the corresponding ratio, for example, spironolactone 2 tablets, furosemide 1 tablet, when the fluid retention is obviously recovered, due to the correction of heart failure symptoms, it is necessary to reduce the dosage of the medication, for example, spironolactone 1 tablet, half a tablet of furosemide, the dosage of the medicine should be closely monitored the changes in blood electrolytes. 2. Cirrhosis: first give a small dose of diuretic, and then gradually aggravate, can be used 2:1 ratio for the proportion, such as spironolactone 2 tablets, furosemide 1 tablet, when no obvious discomfort after taking the drug, the review of blood electrolytes are not disturbed, you need to increase the ratio of 5:2, for example, spironolactone 100mg, furosemide 40mg, the process of monitoring the changes in the peritoneal circumference. Therefore, when choosing the combination of spironolactone and furosemide, it should be taken under the guidance of a professional physician, and the ratio should be combined according to different diseases, and the electrolyte situation should be closely monitored after taking the drug.