High bilirubin and indirect bilirubin are mainly considered as hemolytic changes, hepatic factors, and posthepatic factors. If the elevation is not obvious, it is usually not serious. 1. Hemolytic changes: when severe hemolysis occurs in the body, a large number of blood cells are destroyed, resulting in a large increase of bilirubin in the blood, which is generally more serious, and it is necessary to clarify the cause of bleeding in a timely manner and deal with it accordingly. 2. Hepatic factors: when patients have severe hepatitis or liver injury, the destruction of a large number of liver cells leads to the inability of liver cells to correctly process bilirubin, causing a large increase in bilirubin and indirect bilirubin. 3. Post-hepatic factors: Most of the patients are considered to have gallbladder or intestinal diseases that cause bilirubin not to be excreted normally, thus causing a large amount of bilirubin and indirect bilirubin elevation, which is usually more serious. When bilirubin and indirect bilirubin are elevated, it is necessary to clarify the cause of the elevation as soon as possible and treat accordingly to avoid delaying the condition.