If the patient has white lower lips.1, first of all, we should consider the factors of ischemic disease, such as patients with severe anemia, or obvious poor nutritional status, will lead to white lower lips due to insufficient blood supply.2, secondly, we should take into account the toxicity of the factors, such as food poisoning will be patients with white lips.3, and then some of the cardiac origin of disease, such as coronary atherosclerotic heart disease, myocarditis, pericarditis, infection, hypertrophic obstructive cardiomyopathy and other factors leading to myocardial ischemia. In some diseases of respiratory origin, such as chronic bronchodilatation and pulmonary hypertension, the oxygen saturation of the arteries is insufficient, and there will be whitening of the lips and mouth.5 Finally, when the patient is in shock due to various reasons, there will be whitening of the lips and mouth accompanied by yellowish-white color of the face. The patient will have white lips accompanied by a yellowish-white color.