Herpes simplex virus type 2 IgM positivity indicates the presence of herpes simplex virus type 2 infection in the patient. Usually herpes simplex virus type 2 IgM positivity indicates that the patient has an acute infection and is in the active stage of infection and is contagious. Herpes simplex can be transmitted mainly through close contact, and predisposing factors include immunocompromise, exertion, skin trauma, exposure to cold, and stress. If there are no symptoms, no treatment can be needed. If the patient develops symptoms of herpes simplex, the patient should be treated with medication as prescribed by the doctor, such as antiviral drugs like acyclovir, vasiclovir, etc., which can also be combined with topical 3% acyclovir ointment, 1% penciclovir ointment, and glycerol lotion. If secondary infection exists, it is also necessary to use mupirocin ointment, etc. in combination. It is recommended that patients who are IgM positive for herpes simplex virus type 2 be treated under medical supervision.