Generally, painkillers can only relieve the pain caused by anal fissures and not cure them. Anal fissure is a small ulcer formed after cracking the skin layer of the anal canal below the dentate line, which is mostly seen in young and middle-aged people. The main role of painkillers is to relieve pain caused by various factors and not related to the treatment of anal fissure. There are non-surgical and surgical treatment options for anal fissure. Surgical treatments include anal fissure resection and internal anal sphincter dissections. People suffering from anal fissure should also pay attention to rest in daily life, keep the anus locally clean and dry, change and wash underwear diligently, have a light diet, eat more foods rich in fiber, and drink more water to facilitate defecation. Patients with anal fissure are advised to go to the hospital as early as possible for consultation and early treatment.