Gastric acid reflux may cause hiccups. The esophagus extends through the diaphragm to the stomach, when the esophageal sphincter relaxes, a large amount of gastric acid reflux into the esophagus, at this time a large amount of reflux of gastric acid will also stimulate the adjacent diaphragm, when the diaphragm is stimulated by gastric acid, hiccups will occur. Moreover, long-term reflux of gastric acid, stimulate the wall of the esophagus caused by esophagitis, a large number of inflammatory factors will stimulate the diaphragm, hiccups will occur. Therefore, hiccups caused by acid reflux is a normal pathological phenomenon, which may be caused by severe gastritis, gastric ulcer, reflux esophagitis, etc. At this time, it is recommended that the patient look for the cause of acid reflux, and reduce acid reflux from the root cause to reduce the hiccups symptoms.