The occurrence of tumor is inseparable from environment, diet, emotion, economy and other factors. Liu Junbao, Department of Traditional Chinese Medicine, Henan Provincial People’s Hospital 1.Moderator: How does traditional Chinese medicine know the name of malignant tumor? Expert Liu Junbao: Tumor is an ancient disease. There is a record of “tumor” in the oracle bone inscriptions excavated from Yin Market. In the Han Dynasty, Liu Xi defined it as “tumor, also known as flow, is a tumor caused by blood flowing together. In the Zhou Dynasty, there was a position of ulcer doctor, whose main treatment scope included “swelling and ulcer”, that is, tumor diseases. 2.Moderator: Mr. Liu, can you please tell us what is the relationship between tumor and environment, diet, emotion and economy in the eyes of Chinese medicine? Expert Liu Junbao: Cancer comes from the environment, first of all, it has obvious geographical characteristics. According to the survey, the incidence rate of esophageal cancer is higher in arid mountainous and hilly areas, liver cancer is higher in tropical and subtropical coastal humid and rainy areas, and lung cancer is higher in industrial areas. Secondly, it shows obvious occupational characteristics, with high incidence of lung cancer among tin mine workers, bladder cancer among synthetic dye factory workers, and leukemia among those exposed to radioactive substances. Environmental pollution plays a very important role in cancer incidence triggers. Diet: disease enters from the mouth, and people who like to eat too salty food are prone to stomach cancer. Cured, smoked and baked foods, such as salted meat, salami, smoked fish, ham and pickled vegetables, are all prone to cancer. The Japanese have more people suffering from stomach cancer, which may be related to this. High-fat diet is prone to breast cancer and intestinal cancer. Emotion: People have seven emotions, such as joy, anger, worry, thought, sadness, fear and fright, among which bad emotions have an important relationship with the occurrence of cancer. People who are sulking at meals are prone to stomach cancer, and those who are withdrawn and less talkative and negative and out of touch are more prone to liver cancer than other personalities. Experimental studies have shown that people’s bad emotions will reduce the immune function’s defense ability against carcinogenic substances through the central nervous system and increase the risk of cancer. Economy: The incidence of stomach cancer in the United States was higher in the 1930s and has been declining since then. In Japan, the incidence of stomach cancer and liver cancer decreased year by year after 1950s. Generally speaking, the incidence of cancer in developed countries is low, while that in developing countries is high. The relationship between other diseases: research proves that people who often suffer from upper respiratory tract infections and intestinal infections have little chance of cancer, which may be related to the fact that viruses and bacteria activate the human immune system and the immune monitoring function is particularly strong. We often hear that “a certain person usually does not have any disease, but when he has a disease, it is cancer”, which is completely in line with medical theory. Therefore, the muscle that often suffers from general diseases is normal, which is both in line with medical theory and philosophy. Chinese medicine uses the theory of “cutting off and reversing” to prevent and treat tumors, and it has an anti-tumor metastasis effect. 3. Host: Mr. Liu, what is the significance of Chinese medicine in the treatment of tumors? Expert Liu Junbao: At present, the mortality rate of malignant tumors is increasing year by year, and the traditional methods of treating tumors are surgery, chemotherapy, radiotherapy and targeted therapy. In the past, it has been thought that TCM can only reduce the toxicity and increase the effectiveness, that is, to reduce the toxic side effects of radiotherapy and enhance the effect of radiotherapy, but in recent years, the theory of “truncation and reversal” applied in TCM is of great significance in preventing tumor metastasis and has an anti-tumor metastatic effect. 4.Moderator: Can you talk to us about the nature of truncated torsion and the treatment method of “truncated torsion” and anti-tumor metastasis? Expert Liu Junbao: In the “Treatise on Warm Epidemic”, Ye Tianshi of Qing Dynasty proposed the identification of Wei Qi and Ying Blood. “In the Wei sweat of the can also, to the qi can only clear the qi. Into the camp can still penetrate the heat to turn the qi, into the blood will be afraid of blood depletion and blood movement, straight must cool the blood to disperse the blood.” Jiang Chunhua, a famous Chinese medicine expert, based on the theory of warmth and disease identification, put forward the academic viewpoint of “intercept and reverse”, whose main spirit is to grasp early treatment, rapid control of the disease, grasp the law of identification, take decisive measures and special efficacy of prescriptions and medicines, directly attack the nest of the disease, quickly eliminate the pathogen, if the cause of the disease can not be quickly eliminated, but also to If the cause of the disease cannot be eliminated quickly, it is also necessary to save the danger and intercept the change, intercept the evil from going deeper, stop the disease from deteriorating as much as possible, and buy time for further treatment of the tumor. “Specifically, by adjusting the evil to positive ratio and the dynamics of the disease body, the disease will turn from dangerous to safe, from heavy to light, from urgent to slow, and from reverse to smooth, and then the evil will recede and be restored and turn into a straight path. The most terrible thing about tumor is metastasis. According to the theory of “treating the untreated disease” and the treatment rule of “truncation and reversal” in Chinese medicine, the tumor can be turned into a safe one by advance layout. The following are the specific methods of the author’s clinical application of truncated torsion. （Malignant tumors, especially in the middle and late stages, often have fever, enlarged mass, local burning, pain, thirst, red tongue with yellow coating and counted pulse, which belong to the evidence of internal trapping of evil heat. The treatment is to prevent the cancer toxin from invading the lung and liver. The formula includes Bupleurum, Bupleurum, Saxifrage, Tu Fu Ling, Chrysanthemum, Seven-leaved One-branch Flower, Di Ding, Half-sided Lotus, Half-branch Lotus, Whitehead, and Golden Silver Flower. The method of clearing heat and detoxifying toxins plays a reversing effect on tumor metastasis to the lung. The lung is a delicate organ, and clearing lung heat can prevent cancer toxins from metastasizing to the lung. There are more pharmacological studies reported on clearing heat and detoxifying anti-tumors, directly inhibiting tumors with the strongest anti-cancer activity, such as alchemilla, sanguisorba, hemipterocarpus, Andrographis paniculata, and donglingcao all have different degrees of tumor suppressing effects. In addition, there are regulation of the body’s immune function, anti-inflammatory and detoxification effects, regulation of endocrine function, and purgative and detoxifying drugs can block carcinogenesis and antimutagenesis. There is experimental evidence that Hepatica spp. has an inhibitory effect on liver cancer, and Huanglian can inhibit the formation of nucleic acid in cancer cells. Dongling Cao can inactivate the activity of sodium pump in tumor cells, and also inhibit the formation of DNA to achieve tumor-killing effect. White flowered snake’s tongue herb, half-branch lotus and half-sided lotus all have certain anti-cancer effects. （Tumors are also known as stone obstruction, stone gangrene, breast rock, stone gall, kidney rock and stone furuncle, which are mostly tangible masses. It is said in the scriptures that “the firm is eliminated” and “the knot is dispersed”. To prevent and control the metastasis of tumor, we can lay out softening and dispersing drugs in advance. Commonly used softening and dispersing drugs include: turtle nail, vine pear root, stone see through, curcuma longa, August zha, seaweed, gua pou, ground dragon, earth turtle, kombu. Modern pharmacological research proves that the main anti-tumor effect of softening and dispersing drugs lies in the direct killing of cancer cells. In clinical practice, we often use the method of softening and dispersing nodules after cancer surgery to prevent cancer cells from metastasizing. If one metastasis has occurred, multiple metastases can be prevented. (3) Method of dispelling phlegm and dampness. The spleen is not healthy, the qi is blocked, and phlegm and dampness coalesce to form lumps, “the spleen is the source of phlegm, the lung is the storage of phlegm”. The nucleation of phlegm and dampness into masses is an important factor for tumor metastasis. The treatment is to resolve phlegm and dispel dampness. The formula is based on the addition and subtraction of Guiding Phlegm Tang. The commonly used drugs for removing phlegm and dampness are: Cichorium, Sempervivum, Saponaria, Bombyx mori, Scape Drabble, Seafoam, Qian Hu, Almond, Atractylodes, Green Pores, Seafoam, Loxodendron, Doklam, Patchouli, Perilla, and Raw Coix seed. Modern pharmacological research proves that the method of removing phlegm and dampness has a direct inhibitory effect on tumors. （Qi and blood play an important role in the formation of tumor. “Qi is the handsome of blood, blood is the mother of Qi”, Qi stagnation and Qi deficiency can lead to blood stasis and tumor. The commonly used drugs to activate blood stasis include Salvia miltiorrhiza, Wu Ling Li, Wang Bu Liu Xing, Peach kernel, Safflower, Red peony, Trigonella, Curcuma longa, Boswellia, Myrrh, Phellodendron, Leeches, Hypericum perforatum, Turtle, Angelica, Zelenia, Tiger Balm, Stone, Whole worm, and Blood. Modern pharmacological research has proved that blood activating and stasis-transforming drugs have the effect of inhibiting the growth of cancer cells, anticoagulation and fibrinolysis, reducing the formation of cancer emboli, preventing metastasis, improving microcirculation and local hypoxia, augmenting radiotherapy, improving the efficacy of treatment, promoting the softening and absorption of fibrous tissue, and being beneficial to combined liver sclerosis, etc. Some people have done in vitro experiments with safflower and found that safflower has anti-cancer effects, and its tumor inhibition rate reaches The rate of tumor inhibition is over 90%. Curcuma longa and Curcuma longa can promote fibrinolysis and degenerate new capillaries in metastases. Curcumin and tanshinone can both induce cell differentiation and promote apoptosis, and kill cancer cells. Chinese medicine can inhibit the proliferation and metastasis of tumor cells, enhance the efficacy of chemotherapy drugs and improve the immune function of the body. 5.Moderator: What is the application of Fu Zheng method in the treatment of tumor? Expert Liu Junbao: Fu Zheng includes benefiting Qi, nourishing Blood, nourishing Yin and warming Yang. In the treatment of tumor, it should be applied according to the evidence, and the tonic method should not be applied excessively. When the correct application of tonic medicine, the human immunity is improved, the autoimmune cells can clear the tumor cells and achieve the purpose of treating tumor. Immunotherapy for tumors became a hot spot in 2014. 6. Moderator: What are the advantages of Chinese medicine in treating tumors? Liu Junbao expert: Traditional view is that Chinese medicine can reduce the toxic side effects of radiotherapy in the treatment of tumors. I use Chinese medicine in clinical practice to directly treat tumors and anti-tumor metastasis, especially for elderly people over 70 years old who cannot tolerate surgery, radiotherapy and chemotherapy, they can directly use Chinese medicine for anti-tumor treatment and play the advantage of Chinese medicine without toxic side effects. In principle, we can use the method of supporting and eliminating tumors, and the method of eliminating tumors includes softening and dispersing hard knots, clearing heat and detoxifying, removing phlegm, activating blood circulation and removing blood stasis. Chinese medicine for tumor treatment and survival with tumor: Chinese medicine can inhibit tumor cell proliferation, and clinical treatment of tumor with Chinese medicine can find no reduction of tumor before and after treatment, but the concentration of serum tumor markers decreases after treatment. Research dynamics of TCM for tumor treatment: With the deepening of apoptosis research, the research of TCM to induce tumor cell apoptosis shows good momentum. In the prevention and treatment of tumor metastasis, tumor cells can be prevented from metastasizing to bone, liver, lung and brain by clearing heat and detoxifying, dispelling dampness and phlegm, softening and dispersing knots, activating blood circulation and removing blood stasis before tumor metastasis. Clinical pharmacological research, studies have proved that Chinese medicine can inhibit the proliferation and metastasis of tumor cells, enhance the efficacy of chemotherapy drugs and improve the immune function of the body. Modern medicine has made remarkable progress in research concerning targeted therapy. Chinese medicine compound anti-tumor: experiments have shown that; Chinese medicine can inhibit the expression of matrix metalloproteinases, interfere with the interaction between endothelial cells and extracellular matrix, and prevent the formation of tumor vascular network. The research on anti-tumor neovascularization of Chinese medicine provides a theoretical basis for the truncated reversal of tumor metastasis in Chinese medicine. The compound anti-tumor has made great progress, and Huachansu capsule, Antico capsule, Fuzheng anti-tumor capsule, etc. have been introduced one after another.