Glipizide is not usually taken with a meal, and Glipizide should be taken as prescribed by your doctor. Glipizide is usually taken at the same time as breakfast, or before meals. Glipizide is a hypoglycemic drug, and taking it before or during meals can promote insulin secretion and achieve hypoglycemic effect. If Glipizide is taken after a meal, it is not conducive to lowering blood sugar and affects the efficacy of Glipizide. Despite the hypoglycemic effect of Glipizide, adverse reactions such as fatigue, dizziness, headache, diarrhea, gastrointestinal flatulence, etc. may occur with Glipizide. The drug is contraindicated in people who are allergic to the ingredients of Glipizide, type 1 diabetes mellitus, diabetic ketoacidosis, and others. Taking Glipizide should be directed by a doctor and patients should not use the drug on their own.