Closed mouth acne is caused by exuberant secretion of sebaceous glands and abnormal keratinization of hair follicle openings. It can be treated by general treatment, topical medication, chemotherapy and acne removal surgery. 1. General treatment: eat a light diet, keep the skin fresh and clean, keep a happy mood, do not use irritating skin care products, do not eat chili, high fat and high sugar food, do not stay up late, drink alcohol, smoke. 2. Topical medication: Topical medication is the main treatment, you can apply retinoic acid drugs, such as retinoic acid gel, adapalene gel, etc., but also combined with benzoyl peroxide, azelaic acid and other drugs to resist Propionibacterium acnes. 3. Chemotherapy: Fruit acid and salicylic acid can be utilized to interfere with the binding force on the cell surface, accelerating the shedding and renewal of epidermal cells, as well as promoting the reduction of inflammation. 4. Acne Clearance: Use an acne squeezer to squeeze out the contents and reduce acne symptoms. Due to the different degrees of the disease, the choice of treatment is different. When diagnosed with closed mouth acne, it is important to do the treatment prescribed by the doctor and not to self-medicate to avoid adverse consequences.