It is possible that taking Tibolone can cause gastrointestinal disturbances, but it does not happen to everyone. Tibolone is a prescription medication for the treatment of low estrogen symptoms caused by surgical menopause and natural menopause in women, and this medication has been found to cause gastrointestinal disturbances in a few patients, which can lead to lower abdominal pain and other discomforts during clinical use. However, this phenomenon does not exist in all patients, and most patients have no obvious abnormalities after using the drug. In addition, some patients may also experience adverse reactions such as dizziness and headache, abnormal hair growth, itchy skin rash and visual disturbances. This drug is contraindicated in patients who are pregnant, breastfeeding, suspected (diagnosed) breast cancer or estrogen-dependent malignancy, unexplained vaginal bleeding, untreated endometrial hyperplasia, previous or current venous thrombosis. This drug is also contraindicated in persons who are hypersensitive to Tibolone, in persons with acute liver disease or a history of liver disease and normal liver function that has not recovered, in patients with active or recent arterial thrombotic disease, and in patients with known thrombosis-prone disorders (e.g., protein S or C, antithrombin deficiency). Tibolone must be used under the supervision of a medical professional and in the event of the presence of physical discomfort.