It is normal to see a significant decrease in DNA after interferon injection because interferon itself has an anti-hepatitis B virus effect. After the injection of interferon, the number of hepatitis B virus values will generally show a significant decrease, because interferon itself has the effect of anti-hepatitis B virus, but also can enhance the body’s immune ability. Interferon injection can increase the conversion rate of Hepatitis B E antigen and Hepatitis B surface antigen, and the relapse rate is relatively low. After the injection of interferon, if the number of hepatitis B virus replication has not decreased significantly, then you can combine the treatment with nucleoside antiviral drugs such as lamivudine, entecavir, adefovir, etc. Or stop using interferon, and use only the nucleoside antiviral drugs, which can enhance the immune system. Or stop using interferon and use nucleoside antiviral drugs alone. Clinical use of interferon should pay attention to the observation of its adverse reactions and contraindications, pay attention to patients who are allergic to the drug can not be used, the injection site may cause redness, swelling, pain and other adverse reactions, it is recommended to consult the Department of Infectious Diseases of regular hospitals.