Pyrazinamide belongs to the first line of anti-tuberculosis drugs and is effective against tuberculosis. Pyrazinamide is a nicotinamide drug that belongs to the first line of anti-tuberculosis drugs. Pyrazinamide can be bactericidal against Mycobacterium tuberculosis and is not cross-resistant when used with other drugs. Adverse effects of pyrazinamide include gastrointestinal discomfort, arthralgia, hepatic impairment, and hypersensitivity. No contraindications have been identified. This drug needs to be used under the supervision of a doctor. The treatment of tuberculosis is not through a drug can achieve therapeutic effect, its treatment principle is the early use of drugs, the use of drugs need to be a variety of combined, according to the patient’s tuberculosis bacillus appropriate amount of drugs, drugs need to be regular as well as the whole process of drug use. These five principles are indispensable, so that the patients of tuberculosis is effective treatment. Tuberculosis patients need to be under the guidance of the doctor to use a combination of drugs.