Taking insulin before drinking alcohol has the potential to produce adverse effects such as hypoglycemia and in severe cases, even coma. Therefore, it is not recommended to consume alcohol during insulin administration to avoid adverse consequences. Alcohol needs to be metabolized by the body’s liver, and ethanol in alcohol entering the liver has the potential to inhibit hepatic glucose output. Drinking alcohol during insulin administration may increase the risk of hypoglycemia, and in severe cases, may cause coma. If hypoglycemia occurs, the patient should take glucose or sugar-sweetened beverages and sugar cubes by mouth, and if necessary, should be sent to the hospital for treatment immediately. It is recommended that diabetic patients should strictly control the consumption of alcohol. Frequent consumption of alcohol also damages the human pancreas, especially if it is consumed in large quantities over a long period of time, which may lead to alcoholic cirrhosis of the liver, alcoholic hepatitis and other diseases. The use of insulin requires consultation with a medical professional.