Adults with prolonged cough may be caused by gastroesophageal reflux, nasal reflux, allergic cough, cough variant asthma and so on. It is recommended to find out the cause of the cough, can be given to change bad habits, give to promote gastrointestinal dynamics, antihistamine, hormone drugs for treatment. 1. Gastroesophageal reflux (GERD): frequent overeating, going to bed right after eating, increased pressure in the stomach, leading to reflux of gastric acid to irritate the throat, causing cough. It is recommended to change the habit that can not be changed, if necessary, give domperidone, mosapride can increase the gastrointestinal tract power. Give omeprazole, bismuth potassium citrate can reduce gastric acid secretion and promote mucosal recovery. 2. Nasal reflux: rhinitis, sinusitis and other nasal diseases lead to increased secretion, nasal mucus along the nasopharynx reflux into the oral cavity, causing irritating cough, it is recommended to combine with the doctor’s advice to give rhinitis tablets, loratadine and other drugs treatment. 3. Allergic cough: allergic patients inhaling pollen, willow, irritating gas can cause allergic cough. It is recommended to give antihistamines such as loratadine and cetirizine for clear diagnosis, which can help to relieve. 4. Cough variant asthma: Cough variant asthma is considered to be related to the dual role of heredity and environmental factors, and the patient mainly manifests dry cough, which usually lasts for a long time. Bronchodilators such as ipratropium bromide powder inhaler can be given. Hormonal drugs such as prednisone acetate can provide quick relief. Adults with prolonged cough may also be associated with bronchitis, pneumonia and other diseases. If the cough lasts for a long time, it is recommended to go to the hospital for a detailed examination to clarify the cause of the cough and then treat the cause. The above medications should be used under the guidance of a physician.