Whether syphilis is difficult to treat is related to whether the treatment is timely and standardized as well as the stage of syphilis. Syphilis is a sexually transmitted disease caused by syphilis spirochete infection, clinically categorized as stage 1 syphilis, stage 2 syphilis and stage 3 syphilis. It will involve all organs of the patient and seriously threaten the patient’s life and health safety. Syphilis spirochetes are sensitive to penicillin and have low drug resistance, so penicillin is generally used as the first choice of drug for the treatment of syphilis. For patients with stage I and II syphilis who are not accompanied by organic damage of various systems, timely and standardized use of penicillin treatment, the efficacy and prognosis is better. Patients with stage III syphilis are often accompanied by organic damage to various systems, in which case the difficulty of treatment will increase significantly, and the organic damage to various systems is irreversible. Therefore, whether syphilis is difficult to treat is closely related to whether the treatment is timely, standardized and the stage of syphilis, it is recommended that patients with syphilis diagnosed with timely medical treatment, standardized treatment, so as to avoid delaying the condition of the serious consequences.