Glans pearlescence may be a physiological developmental variant and is neither a tumor nor an STD. The clinical manifestations are white, skin-colored or light red papules that do not fuse with each other and are arranged in one or several rows along the coronal sulcus at the posterior margin of the glans. It is commonly known as “glans pearly whites”. In medicine, it is named as glans pearl rash or pearly penile papulosis. Medical experts have confirmed that the structure is normal connective tissue hyperplasia after making pathological sections. The etiology has not been clarified and the assertion relies mainly on the location and morphology of the distribution of the rash. The disease may be a physiological developmental variant and is neither a tumor nor a venereal disease. The clinical manifestations are white, skin-colored or light red papules that do not fuse with each other and are arranged in one or several rows along the coronal sulcus at the posterior margin of the glans. It is commonly known as “glans pearly whites”. In medicine, it is named as pearly penile papulosis. Medical experts have confirmed that the structure is normal connective tissue hyperplasia after making pathological sections. The cause of the disease is not yet clear, and the conclusion depends mainly on the location and shape of the rash distribution. There is no specific treatment for this disease, nor does it require treatment. Often young men they are worried, some about growing a tumor, and some are afraid of getting a sexually transmitted disease. In the sexual medicine consultation letter, there are not a few who ask about this lesion, and they describe it very specifically: the rash is the size of a small rice grain, similar in color to the surrounding skin, not painful or itchy, and although it does not affect urination or sexual life, the psychological pressure is very high. The disease does not have any effect on health or the physical function of the penis. The most important thing for those who suffer from this disease is to recognize the disease and free themselves from fear and worry.