A 36-year-old pregnant woman belongs to the higher age group, the risk of chromosomal abnormality increases, it is recommended to do amniocentesis, if the mother can not accept the risk, she can also choose non-invasive DNA. 1.non-invasive DNA: can be used as a prenatal prevention of birth defects check, mainly extract maternal peripheral plasma free DNA for testing, from which to understand by congenital developmental abnormalities, to exclude chromosomal genetic disorders. Generally, the test is carried out at 12-22 weeks of pregnancy to screen the three pairs of chromosomes 21, 18 and 13. 2. Amniocentesis: The main purpose of the test is to extract amniotic fluid, from which it can be observed whether there will be embryonic developmental malformations and chromosomal abnormalities. It is usually performed at 16-24 weeks of pregnancy to screen 23 pairs of chromosomes and is the gold standard for diagnosis. 36-year-old pregnant women belong to the high age of pregnancy, pregnancy test needs to pay special attention, whether non-invasive DNA or amniocentesis, need to combine their own physical conditions, age, as well as the risk value of the fetus suffering from chromosomal disorders, to make a judgment.