The consequence of nerve invasion by cancer cells is to cause pain and dysfunction of the corresponding nerve. The consequences of invasion of different nerves are different, for example, esophageal cancer invading the recurrent laryngeal nerve can lead to hoarseness, choking and coughing of drinking water. Invasion of the spine and lumbar spine by cancer cells can lead to obvious pain, paraplegia and limb movement disorders. Infiltration of brain nerve by cancer cells may lead to headache, vomiting, aphasia, blindness, limb weakness, hemiparesis and other symptoms, and in serious cases, it may lead to brain herniation, coma and even death. Pulmonary acinar cancer invades the sympathetic nerve trunk of the neck, which can lead to Horner syndrome, manifested as sunken eyes, drooping upper eyelids and little or no sweating on the face. Nasopharyngeal carcinoma invading the trigeminal nerve may cause obvious trigeminal neuralgia, facial palsy, or even mask face.