HC2 is a qualitative test for human papillomavirus (HPV) infection. Its positivity indicates the presence of HPV infection, which can be transmitted through sexual contact and requires active treatment. HC2 is taken from female cervical secretions and is a qualitative test. HC2 positivity indicates the presence of HPV infection, but it is not certain of the HPV type, so it is necessary to continue to improve the typing HPV test. However, HC2 positivity can be infected to others through sexual contact transmission, blood transmission, etc. It may also cause cervical cancer, etc. and should be treated actively. HC2 positive can be standardized treatment under the guidance of the doctor, such as the use of fluorouracil, imiquimod and so on. Personal hygiene should be observed in daily life and treatment should be carried out when necessary.