A large pimple next to the nose may be caused by acne, folliculitis and other factors. Whether or not it can go away on its own should depend on the condition, if the condition is mild it may go away on its own, if the pimple is bigger, it usually can’t go away on its own, it can be given topical medication, oral medication, and if necessary, treated by way of surgery. 1. Acne: Acne, also known as pimples, is a common chronic inflammatory follicular sebaceous gland disease of the skin. Acne occurs easily on the face, neck, chest, shoulders and back, and is mainly characterized by pimples, inflammatory papules and pustules. In mild cases, attention to cleanliness, a good work routine, light diet, after a period of time, the rash can subside; in severe cases, it usually can not subside on its own, and can be given clindamycin, fusidic acid, salicylic acid, adapalene, doxycycline and other medications, which is conducive to acne subsidence. 2. Folliculitis: Folliculitis is caused by bacterial infection, which may lead to localized single or multiple red papules and pustules. If left untreated, it may spread outward. Medications such as amoxicillin, fusidic acid, and ichthyol can be given. If the folliculitis has become pus-filled, it is treated by surgical incision and drainage if necessary. Usually pay attention to skin and diet care, do not local stimulation, to avoid leading to aggravation of symptoms. If necessary, go to the hospital dermatology department, specific medication, need to follow the doctor’s instructions to use.