Vulvovaginitis in children should firstly eliminate the causative factors, and secondly, according to different pathogens, local treatment can be used, and systemic treatment can be used when the effect is not good. 1. Eliminate triggers, parents with vulvovaginitis and vaginitis timely treatment, children’s clothing washed separately, and placed in a ventilated and dry place, after urination and defecation should be wiped in a timely manner. Usually pay attention to personal hygiene, try to keep the vulva clean and dry. 2. Localized treatment, obvious symptoms should be tested stool and vaginal secretions. Pseudomonal yeast infection can follow the doctor’s advice to use topical clotrimazole ointment, trichomonas infection can be applied locally clindamycin gel, etc., accompanied by obvious redness, swelling and pain, it is recommended to use topical erythromycin ointment. 3. Systemic treatment, the infection is obvious, local medicine is difficult to control but also according to different pathogens with systemic drugs, such as amoxicillin clavulanate potassium dispersible tablets, metronidazole, etc., if there are parasitic infections, should also be oral anthelmintic, such as albendazole and other treatments. Drugs should be used under the guidance of a doctor, pay attention to a light diet during the use of drugs, do not frequently scratch the local, to prevent the infection aggravated.