Generally there is no flocculent in the stool after metronidazole enema. Stool flocculent is mainly due to intestinal dysfunction, enteritis, intestinal tumors, intestinal parasitosis, etc. It is caused by inflammation of the intestinal tract, causing intestinal mucosal ulceration or erosion, and the appearance of intestinal wall secretions and necrotic intestinal mucosa and other white mucus, which adheres to the surface of the feces. Metronidazole enema can make the drug directly reach the lesion site, with high drug absorption rate and less adverse reactions than systemic medication, which is proved to be a feasible treatment method in clinical work. It can be seen that metronidazole enema is the treatment of intestinal inflammatory diseases, when the patient’s stool flocculent should promptly inform the physician, the physician will be based on the patient’s situation to make a comprehensive judgment, in order to adjust the treatment program.