With HPV51 infection alone, there is a risk of getting cervical cancer, but a lower chance of developing cervical cancer. With HPV51 positivity, there is a risk of getting cervical cancer, but not necessarily developing cervical cancer. Regular follow-up is recommended. Although HPV51 is a high-risk HPV virus, simple infection with HPV51 does not necessarily develop into cervical cancer. Most HPV infections may turn negative on their own. If the test result simply suggests HPV51 positivity, it needs to be further combined with cervical TCT, the surface status of the cervix, the presence of contact bleeding and other elements to comprehensively determine whether it will develop into cervical cancer. It is generally recommended that women who are purely HPV51-positive and sexually active should have annual rechecks for cervical TCT and HPV, so that problems can be detected in a timely manner. If a positive result is indicated, attention should be paid, and if necessary, active hospitalization should be carried out to make a clear diagnosis by performing colposcopic multiple-point cervical biopsy.