Itchy hands at night may be caused by physiological factors such as not paying attention to hygiene, or it may be caused by scabies, hives, eczema and other diseases. 1. Physiological factors: If you don’t pay attention to hygiene, local cleaning before going to bed is not in place, it may lead to very itchy hands at night. 2. Scabies: the cause of the disease is mainly caused with the scabies mite parasites on the human epidermis, the patient’s finger cracks, wrists and other parts of the pimples, blisters, itching and other symptoms, usually at night the degree of itching will be aggravated. 3. Urticaria: the cause of the disease may be related to allergies, infections, mental and other factors, the patient’s self-conscious symptoms for the itchy skin, itchy parts of the red or pale-white masses, masses can be every day or intermittent episodes, if the hands of the hand at night, the masses, there may be very itchy hands. 4. Eczema: due to a variety of internal and external factors, there can be hand rash, itching and other symptoms. At night, the environment is quiet, people’s attention is more concentrated, the senses will be amplified, a little itch will be amplified, appearing at night hand very itchy situation. There are more reasons for itchy hands at night, after excluding physiological factors, it is recommended to go to the hospital to clarify the cause of the disease.