In mild cases of hand, foot and mouth disease there are no sequelae; there is a rash on the mouth, skin and feet, and when the rash subsides, there are no sequelae. However, for HFMD with severe symptoms, especially if it is combined with encephalitis, if it is combined with encephalitis and there are seizures, it depends on how long the child has been having seizures. When the child recovers, an MRI will be done, and the child’s development, movement, language, and intelligence will also be judged, and there may be different degrees of sequelae, and the presence or absence of sequelae will be reassessed based on clinical judgment. In some cases, HFMD may be combined with pneumonia and myocarditis. Pneumonia and myocarditis, in general, depends on the recovery of the child, and there is usually no problem when the child recovers well. But myocarditis, when serious, to do cardiac ultrasound, to clarify whether there is no cardiac function, cardiac function to determine whether there is no affected, in the acute stage should be actively nutritional myocardial treatment. If it is only a case of skin fever, generally there will be no sequelae.