Anti-double-stranded DNA antibody is a specific antibody for SLE, which is very meaningful for diagnosing SLE. Meanwhile, the level of anti-double-stranded DNA antibody is positively correlated with the condition of lupus, and if the positive rate of this antibody is high, it means that the condition of SLE is not yet fully controlled and needs active treatment. After systematic treatment of SLE, such as the application of glucocorticoids combined with immunosuppressants, the anti-double-stranded DNA antibody can turn negative, so this antibody is not only a diagnostic antibody for SLE, but also plays a very important role in the evaluation of the condition of SLE, and it is the most important antibody for SLE.