The most common disease that causes blisters and pain is herpes zoster. The blisters are distributed unilaterally along a person’s limb and are clustered together, called cluster distribution, and the pain is pins and needles or burning, not constant. Blisters with pain are caused by a virus called varicella-zoster virus, which mainly occurs in adults and develops when the resistance and immunity are low, seriously affecting the quality of life. The pain is more pronounced at night. It is recommended to visit the dermatology department of the hospital as early as possible after the occurrence of the above-mentioned condition.