What should I do if my thigh muscles are weak and I can’t stand up? This depends on the cause of the thigh muscle weakness to deal with specific. If a young patient has thigh muscle weakness, mainly bilateral, accompanied by bilateral upper limb weakness, such as a characteristic of light in the morning and heavy in the afternoon, consider that the patient may have myasthenia gravis, but also need to go to the hospital to do thymus CT and electromyography, but also to do cranial magnetic resonance examination. If the thigh muscle weakness is caused by myasthenia gravis, hormones and bromipyridamole can be given orally. If the patient cannot stand up due to thigh muscle weakness, because of a history of hypertension or oral diuretics, then hypokalemia, which is manifested by thigh muscle weakness, can be measured by blood potassium, and if there is low potassium, the patient’s symptoms can be relieved by giving potassium chloride orally. If the thigh muscles are weak and cannot stand up, ask the patient if there is any muscle atrophy, if there is a cold or fever, or if there is a history of vaccination. Consider that the patient may have a muscle disease, such as polymyositis, and need to go to the hospital for kinase examination and electromyography. In addition, if there is muscle atrophy and also muscle weakness in both upper extremities, for middle-aged and elderly patients to consider the possibility of motor neuron disease, you need to go for electromyography and lumbar puncture examination.