Puffiness and pain in the lower eyelid area may be caused by granuloma, acute cellulitis of the eyelid and herpes blepharitis. 1. Blepharitis: It is most common in children and is usually caused by an acute bacterial infection of the eyelid glands or eyelash follicles due to a lack of eye hygiene. 2. Acute cellulitis of the eyelids: usually due to the spread of localized inflammation of the eyelids, mostly in patients with low body resistance or immunodeficiency diseases. 3. Herpetic blepharitis: It is caused by herpes virus infection of the skin of the eye, and can also be manifested as swelling and pain in the lower eyelid. The patient should go to the ophthalmology department of the hospital for examination in time, and after a clear diagnosis, the doctor will formulate a reasonable treatment plan.